Set in 1972, "The Mighty Macs" tells the story of a sassy 23 year old tomboy whose life has been filled with a series of setbacks. On the brink of giving up and moving to the next phase of her life, she takes one final shot at being the head basketball coach at Immaculata College - an all girls catholic school. With help from the nuns, she finds the courage and faith to lead her team along the improbable journey of winning the first national championship in women's basketball.